Profile
Yande Guo, PhD
Research Associate
guo@wayne.edu
PhD, Department of Chemistry and Biochemistry, University of South Carolina, 2002
12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) is an important bioactive metabolite of arachidonic acid. There is evidence that 12(S)-HETE plays a key role in tumorigenesis and enhancement of tumor cell metastatic capacity. Initial studies suggest that the pleiotropic effects of 12(S)-HETE on tumor cells are mediated by eicosanoid receptors which are possibly G-protein coupled receptors (GPCRs). The main aims are to clone 12-HETE receptor from human prostate cancer cells and to unveil its role in cancer progress and metastasis.
guo@wayne.edu
Education
MS, Institute of Genetics, Chinese Academy of Science, China, 1989PhD, Department of Chemistry and Biochemistry, University of South Carolina, 2002
Project & Aims
Characterization of a Novel 12(S)-HETE Receptor and Role in Prostate Cancer Progression12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) is an important bioactive metabolite of arachidonic acid. There is evidence that 12(S)-HETE plays a key role in tumorigenesis and enhancement of tumor cell metastatic capacity. Initial studies suggest that the pleiotropic effects of 12(S)-HETE on tumor cells are mediated by eicosanoid receptors which are possibly G-protein coupled receptors (GPCRs). The main aims are to clone 12-HETE receptor from human prostate cancer cells and to unveil its role in cancer progress and metastasis.